Category: Pregnane X Receptors

protease inhibitor

Residues not contacted with the antibody are in green

Residues not contacted with the antibody are in green. unbound F2 (white). Best right -panel: Position of RII from RII/R217Fstomach complicated (F1 C green, F2 C crimson) with unbound RII (white). Bottom level right -panel: Position of F1 from RII/R217Fstomach complicated (F1 C green, F2 C crimson) with F1 from unbound RII (white).(TIFF) ppat.1003390.s001.tif (9.2M)…
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Kubicek, S

Kubicek, S., R. epigenetic dysregulation involving interactions between histone deacetylation and hypermethylation is responsible for targeted repression of IP-10 and potentially other antifibrotic genes in fibrotic lung disease and that this is amenable to therapeutic targeting. Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease characterized by exaggerated extracellular matrix deposition and aggressive structural remodeling.…
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