By E18
By E18.5, the membrane crescent of Fz3 was not detectable in the mutant (Fig. V-shaped stereociliary bundle (or hair bundle) with intrinsic structural polarity: the actin-based stereocilia are organized into rows of graded heights, forming a staircase-like pattern. Furthermore, auditory hair bundles are uniformly ONX-0914 oriented across the OC, with the V pointing toward the…
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