Interestingly, even the residual subpopulation of perimeter APPL1 endosomes in starved cells were sensitive to Akt inhibition (Fig
Interestingly, even the residual subpopulation of perimeter APPL1 endosomes in starved cells were sensitive to Akt inhibition (Fig. migration. Thus, Dyn1- and Akt-dependent perimeter APPL1 endosomes function as a nexus that integrates signaling and receptor ABBV-4083 trafficking, which can be co-opted and amplified in mutant p53Cdriven malignancy cells to increase migration and invasion. Introduction Malignancy…
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