Differences in physiological features, such as hypoxia-related low pH, excessive production of ECM and increased proteolysis, distinguish sound tumors from healthy tissues [112,113]
Differences in physiological features, such as hypoxia-related low pH, excessive production of ECM and increased proteolysis, distinguish sound tumors from healthy tissues [112,113]. hurdles, such as increased on-target off-tumor toxicities, sparse T-cell infiltration and impaired T-cell quality due to the presence of an immunosuppressive tumor microenvironment, which affect the security and limit efficacy of CD3-bispecific…
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